Indeed, the issue quoted by souney et al was from 1972. Synthesis, spectroscopic, and thermal investigations of. Ponstel mefenamic acid side effects, images, uses, dosage. Stephens wh, elghobarey af, macleod mm, buchanan ww. In this study mefenamic acid was formulated as nanoparticle drug delivery system using ethyl cellulose and eudragits100 as polymers. Studying the assay and the effect of temperature and sun.
It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid. Central nervous system toxicity of mefenamic acid overdose compared with other nsaids. Mefenamic acid is a nonsteroidal agent with antiinflammatory, analgesic and antipyretic action. Oral mefenamic acid 500 mg was effective at treating moderate to. When compared with placebo, treatment with mefenamic acid resulted in significant decreases in the frequency and severity of the. Further studies regarding the effects of ginger on other symptoms associated with dysmenorrhea and efficacy and safety of various doses and treatment durations of ginger are warranted. Analogous to mefenamic acid this compound may be synthesized from 32tu2 chlorobenzoic acid u32t and 32tu2, 3 dimethylaniline u32t. It is also used to decrease pain and blood loss from menstrual periods. It is not widely used in the united states due to its side effects and high cost compared to other nsaid. The effect of mefenamic acid and melissa officinalis. European journal of rheumatology and inflammation 1983. Comparative study on solubility enhancement methods for. The normal dose is 500mg three times a day, starting on the. Mefenamic acid methocel tablets mixed powder was evaluated.
Spectrophotometric methods have been developed for the simultaneous estimation of mefenamic acid and paracetamol 3,4, mefenamic acid and ethamsylate 5,6 and mefenamic acid and drotaverine hydrochloride in combination drugs. International journal of pharmaceutical and clinical research 2017. The pairing of kcnq1 and kcne1 subunits together mediates the cardiac slow delayed rectifier current i ks, which is partly responsible for cardiomyocyte repolarization and physiologic shortening of the cardiac action potential. To compare the effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. Mefenamic acid a nonsteroid antiinflammatory agent. Article pdf available in world journal of pharmacy and. Comparison of effectiveness of mefenamic acid and ibuprofen in treatment of rheumatoid arthritis.
Treatment of primary dysmenorrhea with mefenamic acid. The concentration of mefenamic acid is determined using the previously prepared calibration curve using standard solution of mefenamic acid. Spectrophotometric method for the determination of flufenamic and mefenamic acids. A comparative trial of the efficacy of mefenamic acid and. Starch was used as filler and magnesium stearate was used a lubricant. Ibuprofen superior meienamic acid superior ibuprofen meienamic acid the journal of international medical sideeffects were noted in twentyfive patients. The powders were premixed for 1 min at an impeller. Mefenamic acid oral capsule is a prescription drug used to treat mild to moderate pain and dysmenorrhea menstrual pain. Development of dissolution test method for drotaverine hydrochloride mefenamic acid combination using derivative spectrophotometry panikumar d anumolu1,2, sunitha gurrala2, venkat raju yeradesi2, sathesh babu r puvvadi3 and subrahmanyam vs chavali3. Hemodialysis of mefenamic acid in uremic patients american. A total of 194 treated cycles could be evaluated, 110 cycles with mefenamic acid and 84 with placebo. Comparison of the effectiveness of fennel and mefenamic acid. Acid base titration of ibuprofen in tablets ibuprofen is an organic compound its chemical name is rs242methylpropylphenylpropionic acid widely used as nonsteroidal antiinflammatory drug applied in fever, arthritis, and as pain reliever.
In particular, 22,3dimethylphenyl aminobenzoic acid mefenamic acid. Sep 23, 2015 mefenamic acid ponstel is an oral drug used shortterm to treat pain, including menstrual cramps. Mefenamic acid drug showed a peak in the region 1242, and capryol with mefenamic acid showed a peak in region 1262, mefenamic acid with span 80 showed a peak in the region 1247, mefenamic acid with propylene glycol showed a peak in the region 1214 which all indicate the presence of cn functional group in them. Mefenamic acid mef ischemically 22,3dimethyl phenyl amino benzoic acid. It was concluded that mefenamic acid and ibuprofen had an analgesic and antiinflammatory effect which was not significantly different in the dosages employed. The formulation of the mefenamic acid tablet of 250 mg used for this study was prepared according to table 1. Comparative dissolution studies for mefenamic acid. Mefenamic acid is used to relieve mild to moderate pain, including menstrual pain pain that happens before or during a menstrual period. Stability indicating method for the determination of. A randomized, doubleblind, crossover, placebocontrolled design was used to overcome the methodologic criticisms of other medication trials in this condition. The predicted hhb energy and gibbs free energy changes of mefenamic acid dissolution in the solvents studied highly influence the solubility data. A doubleblind, crossover trial of mefenamic acid, sulindac and flurbiprofen in rheumatoid arthritis. Mefenamic acid is a member of the anthranilic acid derivatives or fenamate class of nsaid drugs, and is used to treat mild to moderate pain, including menstrual pain, and is sometimes used to prevent migraines associated with menstruation. Ch 3 2 c 5 h 3 nhc 5 h 4 cooh figure 1 is an effective nonsteroidal agent widely used for the treatment of mild to moderate pains, inflammation, ache, and fever 35.
By continuing to use our website, you are agreeing to our use of cookies. It has been found that mefenamic acid shows high solubility. Spectrophotometric assay of mefenamic acid in tablets using 1. Pdf the bioavailability and pharmacokinetics of mefenamic. Mefenamic acid ponstel, 250 mg four times a day, and placebo were compared in a doubleblind, crossover study conducted in 46 women with primary spasmodic dysmenorrhea. Mefenamic acid compared with ibuprofen in the treatment of. Advanced journal of pharmacie and life science research 1 invitro bioavailability and pharmaceutical evaluation of five brands of mefenamic acid tablets marketed in oman husni mubarak albreiki 1, sokindra kumar 2, shah alam khan 1 1 department of pharmacy, oman medical college, muscat, sultanate of oman. Mefenamic acid is an aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3dimethylphenyl group. Here, we provide a biophysical and pharmacological. Aug 29, 2019 mefenamic acid is a nonsteroidal antiinflammatory drug nsaid. Nsaids like mefenamic acid may affect egg release ovulation in women. Changes in menstrual blood loss volume and duration were assessed using the questionnaire form filled out before the treatment and every month for. The aim of this research was to study the dissolution profile of mefenamic acid from its solid dosage forms caplet and capsule available in the indonesian market with three different dissolution medium.
Mefenamic acid belongs to the biopharmaceutical classification system bcs class ii drug which has lower water solubility but high permeability. Development of dissolution test method for drotaverine. Although classed as a nonsteroidal antiinflammatory drug, its antiinflammatory properties are considered to be minor. It works by stopping the bodys production of a substance that causes pain, fever, and inflammation. The infrared absorption spectrum is concordant with the reference spectrum of mefenamic acid. This was a doubleblind comparative clinical trial conducted from september 2006 to february 2007. Aug 20, 2019 mefenamic acid oral capsule is a prescription drug used to treat mild to moderate pain and dysmenorrhea menstrual pain. Mefenamic acid has a strong absorption band at 353 nm with high molar absorptivity but it has poor solubility in most. It is utilized for the shortterm treatment of mild to moderate pain from various conditions. Development and validation of mefenamic acid, dicyclomine hcl. Centre for pharmaceutical sciences, ist, jawaharlal nehru technological university. Three of them, the fast dissolving a and the slow dissolving d and e were. Pdf an insight of nonsteroidal antiinflammatory drug mefenamic. Solubility and dissolution thermodynamic data of mefenamic.
Comparison of the effectiveness of fennel and mefenamic. There are two different compendial methods available for dissolution tests of mefenamic acid solid dosage forms, i. A randomized doubleblind withinpatient study of mefenamic acid compared with ibuprofen was performed on forty patients with rheumatoid arthritis. A method of introducing different additives at different times during the process, i. Available on line journal of chemical and pharmaceutical research. Therefore, the present study aims to develop a stability indicating method for mefenamic acid using rphplc technique. According to the pharmacopoeia of the peoples republic of china 7, the method of identification testing of mefenamic acid in capsule and tablet preparations is based on light absorption spectrophotometry. In patients with renal or hepatic impairment, clearance of metabolites may be decreased. This goes back to normal when mefenamic acid is stopped. Full text pdf journal of applied pharmaceutical science. Menorrhagia and its management the pharmaceutical journal. It is used to relieve mild to moderate pain, including. Similar to other nsaids, mefenamic acid inhibits prostaglandin synthetase.
The purpose of this study was to characterize mefenamic acid ma from commercial samples and samples crystallized from different solvents. Stepwise use of additives for improved control over. Preparation and evaluation of methyl salicylate counter. The chemical structure of paracetamol and mefenamic acid is shown in.
Mefenamic acid is used shortterm 7 days or less to treat mild to moderate pain in adults and children who are at least. There were more complaints on ibuprofen than on mefenamic acid but the difference was not significant. Mefenamic acid is a nonsteroidal antiinflammatory drug. The bioavailability and pharmacokinetics of mefenamic acid. Preparation and properties of rare earth element complexes with mephenamic acid, polish journal of chemistry, vol. Spectrophotometric assay of mefenamic acid in tablets. In this article, the solubility of mefenamic acid in different classes of organic solvents, including polar protic, dipolar aprotic, and apolar aprotics at a range of temperatures from 298 to 323 k are reported. Mefenamic acid is a nonsteroidal antiinflammatory drug used to treat pain. The iks ion channel activator mefenamic acid requires. The use of mefenamic acid in the treatment of premenstrual syndrome pms was investigated in 15 women over six menstrual cycles.
Feb 14, 2017 where can i get more information ponstel. Various techniques used for characterization included microscopy. Ide, molecular structures of metal complexes with mefenamic acid, journal of pharmaceutical and. The bioavailability and pharmacokinetics of mefenamic acid in alloxandiabetic rabbits article pdf available in the tokai journal of experimental and clinical medicine 224. Pdf spectrophotometric method for the determination of. Formulation and invitro evaluation of dry emulsion of mefenamic acid in hard vegetarian capsules html full text.
Mefenamic acid in the treatment of premenstrual syndrome. Comparison of effects of ginger, mefenamic acid, and. It exhibits antiinflammatory, analgesic, and antipyretic activities. If you are 65 or older, use mefenamic acid with care. Single dose oral mefenamic acid for acute postoperative pain in adults. Learn about side effects, warnings, dosage, and more. Mefenamic acid is the drug which comes under the nsaid. Different classes of solvents provide different polarity values, which influence the solubility of pharmaceutical solids. Solidstate characterization of mefenamic acid panchagnula. Preparation and evaluation of mefenamic acid nanoparticles. Mefenamic acid works by reducing hormones that cause inflammation and pain in the body mefenamic acid is used shortterm 7 days or less to treat mild to moderate pain in adults and children who are at least 14 years old. In one small, randomized trial, the prevalence of preterm labor was significantly reduced by mefenamic acid compared with placebo. Therefore, cosmors with reference solubility method is a promising approach to predict the solubility and intermolecular interaction energy of mefenamic acid in different solvents.
The effect of hemodialysis on plasma mefenamic acid levels was studied in four patients on longterm hemodialysis. International journal of research in advent technology, vol. Use of mefenamic acid in the treatment of primary dysmenorrhea. Mefenamic acid counter irritant topical drug deliver nsaids abstract topical delivery of hydrophobic drug with good patient acceptance is a big challenge which is successfully handled by emulgels. Mefenamic acid is a nonsteroidal antiinflammatory drug nsaid that is widely used for the treatment of mildtomoderate pain. A 500mg oral dose of mefenamic aci we use cookies to enhance your experience on our website. Mefenamic acid, a nonsteroidal antiinflammatory drug, has been identified as an i ks activator. Mefenamic acid works by reducing hormones that cause inflammation and pain in the body. Central nervous system toxicity of mefenamic acid overdose. Preparation and evaluation of mefenamic acid nanoparticles by. International journal of pharmacognosy and phytochemical research 2016. Dissolution profile of mefenamic acid solid dosage forms.
View the article pdf and any associated supplements and figures for a period of 48 hours. Fifty years ago, when weiss et al studied mefenamic acid, a nonsteroidal anti inflammatory drug, as a promising antipyretic drug in children, stable liquid. Feb 14, 2016 the aim of this research was to study the dissolution profile of mefenamic acid from its solid dosage forms caplet and capsule available in the indonesian market with three different dissolution medium. Mefenamic acid compared with indomethacin and placebo in. A study in kerman, islamic republic of iran in 2002 compared the effectiveness of fennel and mefenamic acid on pain relief in primary dysmenorrhoea. Ginger was as effective as mefenamic acid and ibuprofen in relieving pain in women with primary dysmenorrhea.
Mefenamic acid mfa and nicotinamide nic cocrystal formation in comilling treatment was investigated by xray powder diffractometry. According to the british pharmacopoeia 2002 2 and indian pharmacopoeia 6, mefenamic acid in capsule and tablet preparations are identified by examination using infrared absorption spectrophotometry as the following procedure. Mefenamic acid, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal antiinflammatory drugs nsaids. Mefenamic acid is in a class of medications called nsaids. In the absence of additives, at optimized conditions, mef crystals were prepared in the size range of 0.
Trial of mefenamic acid rheumatology oxford academic. Fifty years ago, when weiss et al studied mefenamic acid, a nonsteroidal antiinflammatory drug, as a promising antipyretic drug in children, stable liquid. The was to prepare emulgel of mefenamic acid, a nsaid, using. Participants were 150 students 18 years old and over with primary dysmenorrhea from the dormitories of two medical universities who were. Extract a quantity of the capsule contents or powdered tablets containing 0. Dissolution profile of mefenamic acid solid dosage forms in. Halflife 5 times longer in preterm infants compared with adults. Mefenamic acid 200 mg controlled release matrix tablets were. Synthesis, spectroscopic, and thermal investigations of metal. Comparative dissolution studies for mefenamic acid polyethylene glycol solid dispersion systems and tablets.
Mefenamic acid produced complete relief of all the symptoms of dysmenorrhea in 31 88. Each bluebanded, ivory capsule contains 250 mg of mefenamic acid for oral administration. Mefenamic acid is a white to greyishwhite, odorless, microcrystalline powder with a melting point of 230231c and water solubility of. Invitro bioavailability and pharmaceutical evaluation of. Mefenamic acid is a widely prescribed nsaid and used as first line therapy for the treatment of ailments such as arthritis and dysmonorrhoea. The temperature range of the endothermic peak of all the mefenamic acid crystals lies in the range of 224. Available on line journal of chemical and pharmaceutical. Mohammad asif, study of anthranylic acid derivatives. Prediction of mefenamic acid solubility and molecular. There are no adequate reports or wellcontrolled studies of mefenamic acid in pregnant women. Usp, pprc, and biorelevant fasted simulated small intestinal fluid fassif media.
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